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You may also decide to use prednisone as a short-term treatment for pain or as an alternative to prescription medications. The purpose of the present study was to evaluate the safety and efficacy of the second-generation tetracycline antibiotic Rafiganj minocycline after a standardised therapeutic regimen of doxycycline for the treatment of mild to moderate acne. Tetracycline and its derivatives are not addictive in their own right.